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Withodin B™ is a Phytotherapeutic extraction of Withania somnifera, PolygonumMultiflorum, Apis mellifera propolis, Camellia sinensis, Monoatomic Au, and Cinnamomum verum. Using advanced laboratory extraction apparatus & proprietary production protocols, these phytochemicals are known for their S-Spike protein inhibition properties.
SARS-CoV-2 engages human ACE2 through its spike (S) protein receptor binding domain (RBD) to enter the host cell. Recent computational studies have reported that withanone and withaferin A, phytochemicals found in Withania somnifera, target viral main protease. Withanone bound efficiently at the interacting interface of the ACE2- RBD complex and destabilized it energetically. The electrostatic component of binding free energies of the complex was significantly decreased. Withanone as a potent inhibitor of SARS-CoV-2 coronavirus entry into the host cells. Only withanone was found to be docked into the ACE2-RBD complex. It bound at the interface of the ACE2 receptor and RBD, interacted with the residues from both ACE2 and RBD and was thus analyzed further to study its role in weakening or blocking the interactions between the ACE2 receptor and RBD.
SARS-CoV had been shown to exhibit an open reading frame ORF-3a that codes for an ion permeable channel in the infected cells; the activity of the 3a protein may influence virus release. The ORF-3a is also named “New gene” localized between “spike and envelope gene” (SNE) and has been identified in other corona viruses. This includes the SNE of the human coronavirus OC43 (HCoV-OC43) which shows similar ion-channel characteristics as the 3a protein of SARS-CoV. Emodin was identified as an effective component of Polygonaceae to block the interaction of the SARS-coronavirus spike protein (SARS-CoV S protein) with the angiotensin-converting enzyme 2 (ACE2) and to reduce the infection by S protein-pseudo-typed retrovirus. The ACE2 was shown to be a functional receptor for SARS-CoV with a specific binding domain of the S protein. Emodin may contribute to reduced virus release from the SARS-CoV-infected cell through inhibition of the current mediated by 3a protein.
In silico studies have investigated the use of flavonoids in api-compounds as effective therapeutic candidates against COVID-19 by targeting S protein cleavage by host-cell proteases, e.g., TMPRSS2, S protein binding to cell surface receptors such as ACE-II, inhibiting S protein, or S protein binding to the inflammatory B56 unit in PP2A, as well as by interfering with NSPs of SARS-CoV-2, in order to hamper viral replication. Anti-COVID- 19 effects of favonoids in Propolis reported by molecular docking studies elucidate efforts directed toward designing anti-COVID-19 drugs focused on impeding viral entry into host cells, interrupting viral replication, and inhibiting viral-host protein interactions, with the aim of aborting the inflammatory responses induced by viral invasion.
Withodin B™ is uniquely extracted from organic herbs using organic cane alcohol and deep ocean mineral water, as the extraction solvent. Utilizing advanced all-glass apparatus Withodin B™ undergoes hours of reflux extraction that applies heat and ethanol to enhance the bioavailability of the resultant extraction.